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The auto-inhibitory role of the EPAC hinge helix as mapped by NMR.

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The cyclic-AMP binding domain (CBD) is the central regulatory unit of exchange proteins activated by cAMP (EPAC). The CBD maintains EPAC in a state of auto-inhibition in the absence of the allosteric effector. cAMP. When cAMP binds to the CBD such auto-inhibition is released. https://chefesquipmenters.shop/product-category/accessories-heat-lamps/
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