Objectives The purpose of this study was to evaluate the effect of various application methods of one-step self-etch adhesives to microtensile resin-dentin bond strength. Materials and Methods Thirty-six extracted human molars were used. The teeth were assigned randomly to twelve groups (n = 15). according to the three different adhesive systems (Clearfil Tri-S Bond. https://www.homehardware4ues.shop/product-category/structural-material/